New blockers of Pseudomonas aeruginosa virulence

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In the recent work by Swietnicki et al. (BBRC, https://doi.org/10.1016/j.bbrc.2019.04.055), the group showed how to block bacterial transport system in Pseudomonas aeruginosa responsible for secretion of the most potent toxin by the pathogen. The study demonstrated a proof-of-concept how to do it safely, selectively and without killing the pathogen. The strategy relied on disabling the offensive weaponry of pathogen normally used to destroy human cells. Since the pathogen is on the list of ESKAPE pathogens and responsible for severe complications in hospital intensive care units (ICUs) in patients undergoing organ transplants, chemotherapy and receiving antiviral drugs (HIV/AIDS), the strategy may offer an alternative to antibiotics in the future.

The work was performed at the Institute of Immunology and Experimental Therapy of the Polish Academy of Science in Wroclaw, PL and guided by Dr. Swietnicki. Contributing experiments were performed by the group guided by Prof. Krzysztof Marycz at the Wroclaw University of Environmental Life Sciences and students from the Silesian Medical University and Wroclaw Technical University.

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New antibiotics for P. mirabilis and S. aureus

I am organizing a fundraiser to finance development of new antibiotics against Proteus mirabilis. Goal is to collect 900,000 PLN (1 USD=3.38 PLN) towards basic research. Please visit https://lnkd.in/d4N89bW if you want to donate.

Paper describing a proof-of-concept technology approach and the results for Proteus mirabilis and Staphylococcus aureus is available online at https://doi.org/10.1016/j.bbrc.2018.10.189. Compounds are novel and could be used for further development into a new class of antibiotics.

Technology used to come to that point is described under Technology heading.