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New blockers of Pseudomonas aeruginosa virulence

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In the recent work by Swietnicki et al. (BBRC, https://doi.org/10.1016/j.bbrc.2019.04.055), the group showed how to block bacterial transport system in Pseudomonas aeruginosa responsible for secretion of the most potent toxin by the pathogen. The study demonstrated a proof-of-concept how to do it safely, selectively and without killing the pathogen. The strategy relied on disabling the offensive weaponry of pathogen normally used to destroy human cells. Since the pathogen is on the list of ESKAPE pathogens and responsible for severe complications in hospital intensive care units (ICUs) in patients undergoing organ transplants, chemotherapy and receiving antiviral drugs (HIV/AIDS), the strategy may offer an alternative to antibiotics in the future.

The work was performed at the Institute of Immunology and Experimental Therapy of the Polish Academy of Science in Wroclaw, PL and guided by Dr. Swietnicki. Contributing experiments were performed by the group guided by Prof. Krzysztof Marycz at the Wroclaw University of Environmental Life Sciences and students from the Silesian Medical University and Wroclaw Technical University.

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New antibiotics for P. mirabilis and S. aureus

I am organizing a fundraiser to finance development of new antibiotics against Proteus mirabilis. Goal is to collect 900,000 PLN (1 USD=3.38 PLN) towards basic research. Please visit https://lnkd.in/d4N89bW if you want to donate.

Paper describing a proof-of-concept technology approach and the results for Proteus mirabilis and Staphylococcus aureus is available online at https://doi.org/10.1016/j.bbrc.2018.10.189. Compounds are novel and could be used for further development into a new class of antibiotics.

Technology used to come to that point is described under Technology heading.

Computer-Aided Drug Design Conferences

 

 

The conference is organized by Dr. Swietnicki. Its goal is to get together people working on computational drug design (CADD) with application to protein targets. The area is relatively new in Poland and would benefit greatly from exchange of ideas on how to do it a bit differently than what is typically done using a public domain/custom developed solutions.

The last conference was a great success. Many people were interested in more advanced topics, e.g., free energy perturbation methods, protein-ligand optimization and potentially protein-antibody interface redesigning. We would be happy to have speakers dealing with the subject and the sponsoring company presenting a 2-stage workshop. The first stage would be for beginners and the second one-for advanced users.

Schroedinger workshop

The conference will also include a practical demonstration of  Schrodinger’s computational methods offered to researchers. It will require bringing your own laptop for demonstration.

Date: June 14th , 2019

Topic: Enzyme inhibitors

Program:

8:30 a.m.-12 noon

Presentations

12 noon-1 p.m.

Lunch break

1 p.m.-2 p.m.

Presentations

2 p.m.-4 p.m.

Schrodinger workshop including live demo of software by selected users

4 p.m.-5 p.m.

Happy hour (dry)

 

 

Place: Institute of Immunology and Experimental Therapy of the Polish Academy of Science in Wroclaw (www.pan.wroc.pl), Wroclaw 53-114, ul. R. Weigla 12. Lectures will be given in the Main Conference Room (Aula) on the 1st floor.

Registration 

Registration is free and limited to 50 people. More people are welcome to come but there may be problem with free software licenses and planned meals.

Please use  “Registration” page to register. State if you want to attend only or be a speaker. In the latter case, please send the title of proposed talk.

 

Due to personal data protection laws, contact information for registered persons is confidential. If you want it to be made public, please send me an e-mail stating that you give me a permission to post the data on my site. In Poland, it requires  at least a scan of a signed document.

 

Accommodation

  1. Hotel Novotel (https://www.accorhotels.com/gb/hotel-0528-novotel-wroclaw-city/index.shtml), about 1 km from Weigla Street
  2. Platinum Palace Hotel (http://www.platinumpalace.pl/en/), about 1.2 km from Weigla Street
  3. Hotel Podkowa (https://e-turysta.pl/hotel-podkowa-wroclaw-116898.html), about 1 km from Weigla Street
  4. Ibis Budget Wroclaw Poludnie (https://e-turysta.pl/ibis-budget-wroclaw-poludnie-wroclaw-157770.html), about 1.2 km from Weigla Street